An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke
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چکیده
منابع مشابه
A role for ephrin-A5 in axonal sprouting, recovery, and activity-dependent plasticity after stroke.
Stroke causes loss of neurological function. Recovery after stroke is facilitated by forced use of the affected limb and is associated with sprouting of new connections, a process that is sharply confined in the adult brain. We show that ephrin-A5 is induced in reactive astrocytes in periinfarct cortex and is an inhibitor of axonal sprouting and motor recovery in stroke. Blockade of ephrin-A5 s...
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Generation of new axonal sprouts and the process of axonal elongation play a vital role in neural regeneration and repair. The facial nerve axotomy model is a well-established, prototypical experimental paradigm for the systematic study of nerve regeneration and degeneration, providing insights into molecular signals that determine axonal regeneration and neuronal cell death. Interestingly, thi...
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After an incomplete spinal cord injury (SCI), partial recovery of locomotion is accomplished with time. Previous studies have established a functional link between extension of axon collaterals from spared spinal tracts and locomotor recovery after SCI, but the tissular signals triggering collateral sprouting have not been identified. Here, we investigated whether axonal degeneration after SCI ...
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Traumatic brain injury (TBI) causes many long-term neurological complications. Some of these conditions, such as posttraumatic epilepsy, are characterized by increased excitability that typically arises after a latent period lasting from months to years, suggesting that slow injury-induced processes are critical. We tested the hypothesis that trkB activation promotes delayed injury-induced hype...
متن کاملCritical role of trkB receptors in 1 reactive axonal sprouting and hyperexcitability after axonal injury
25 Traumatic brain injury (TBI) causes many long-term neurological complications. Some of these 26 conditions, such as posttraumatic epilepsy, are characterized by increased excitability that 27 typically arises after a latent period lasting from months to years, suggesting that slow injury28 induced processes are critical. We tested the hypothesis that trkB activation promotes delayed 29 injur...
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ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2010
ISSN: 1097-6256,1546-1726
DOI: 10.1038/nn.2674